Isoallolithocholic acid( —— )

Catalog No. M34853 CAS No. 2276-93-9

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Product Name

Isoallolithocholic acid
Note

Research use only, not for human use.
Brief Description

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis.
Description

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation.
In Vitro

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In Vivo

Animal Model:Segmented filamentous bacteria (SFB)-colonized Jax-B6 miceDosage:0.03% (w/w) Administration:In diet, 7 days Result:Was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to control diet in combination with 0.3% (w/w) 3-oxolithocholic acid (3-oxoLCA). Reduced the number of CD45.1+ T effector cells.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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CAS Number

2276-93-9
Formula Weight

376.57
Molecular Formula

C24H40O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (221.29 mM; Ultrasonic (<60°C); H2O : < 0.1 mg/mL (insoluble)
SMILES

[H][C@@]12CC[C@H]([C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](O)CC[C@]12C
Chemical Name

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1. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.?

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